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KMID : 0378019800230090081
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New Medical Journal
1980 Volume.23 No. 9 p.81 ~ p.84
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Changes of Hematocrit, Reduced and Oxidized Glutathione of the Rat Blood Following Ammonium Chloride Intoxication
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Abstract
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Ammonium chloride (NH4CI) intoxication was induced to the rat by injecting 0.8m1 of 6% NH4C1 solution per 100gm of BW intraperitoneally, with or without pre-general anesthesia with nembutal sodium.
The rat was sacrificed by cutting the carotid arteries after the toxic signs (i.e., coma, dyspnea, and tonic convulsion, etc) fully developed.
The hematocrit (Hct) and reduced (GSH) and oxidized glutathione (GSSG) levels of the blood was measured, and compared with the normal.
The results are summarized as follows.
The normal Hct was 48.87±0.6800, while the NH4C1 intoxication group and nembutal pre-anesthesized NH4C1 intoxication group showed significantly (p<0.01) elevated value of 53.96±1.29% and 56.71±2.46%, respectively.
The blood GSH levels of the experimental groups did not change greatly from the normal value of 8.45±0.62pmol/ml, but the blood GSSG level of the NH4C1 intoxication group and nembutal pre-anesthesized NH4C1 intoxication group was elevated to 12.34± 1.03lcmol/ml and 12.68±1.401cmol/ml, respectively, from the normal value of 9.71±1.39 pmol/ml.
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